Drug Uses
Fosamax is indicated for treatment and prevention of osteoporosis in postmenopausal women. For the treatment of osteoporosis, Fosamax increases bone mass and reduces the incidence of fractures, including those of the hip and spine. It is also indicated for the prevention of osteoporosis, treatment to increase bone mass in men with osteoporosis, treatment of glucocorticoid. It is used to treat induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density, treatment of Paget's disease of bone in men and women.
How Taken
Fosamax comes as a tablet to take by mouth. It should be taken once a day in the morning on an empty stomach. Fosamax should be taken with a full glass (6-8 ounces) of plain water. Wait at least 30 minutes after taking Fosamax before you eat, drink, or take other medications. Do not take Fosamax with mineral water, coffee, orange juice, milk, or other dairy products. Do not suck or chew the tablet; swallow the tablet whole. Do not lie down for at least 30 minutes after taking Fosamax. Standing or sitting upright helps you get the full dose and decreases heartburn or the risk of injury to your esophagus.
Warnings/Precautions
Before taking Fosamax, tell your doctor if you have a problem swallowing, such as a narrowing of the esophagus; have esophageal ulcers or an esophageal disease; have a condition that causes low levels of calcium in the body; have kidney disease; have stomach ulcers or other stomach or digestive problems; or are unable to stand or sit upright for at least 30 minutes.
You may not be able to take Fosamax, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Fosamax is in the FDA pregnancy category C. This means that it is not known whether Fosamax will be harmful to an unborn baby. Do not take Fosamax without first talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether Fosamax passes into breast milk. Do not take Fosamax without first talking to your doctor if you are breast-feeding a baby.
Missed Dose
If you take Fosamax every day and you miss a dose, skip that dose and take the next regularly scheduled dose the following day. Missing one dose will not affect your treatment. Do not take two tablets at the same time.
If you take a Fosamax once a week and you miss a dose, take the missed dose on the morning after you remember. Do not take two tablets on the same day. Return to taking one tablet once a week, as originally scheduled on your chosen day.
Possible Side Effects
Stop taking Fosamax if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
Seek emergency or talk to your doctor if you have difficulty or pain when swallowing; chest pain; pain or burning under the ribs or in the back; or new or worsening heartburn.
Other, less serious side effects may be more likely to occur. Continue to take Fosamax and talk to your doctor if you experience abdominal discomfort; stomach upset, nausea, vomiting, diarrhea, or constipation; headache; muscle, bone, or joint soreness or aches; eye pain; a rash; or an altered sense of taste.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Storage
Store in a well-closed container at room temperature, 15-30°C (59-86°F).
Overdose
Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral over dosage. If you do think that an overdose has occurred, call an emergency room or poison control center.
More Information
Follow you doctor's recommendations about drinking alcohol and smoking. These activities are related to decreased bone density.
Antacids and other medicines taken by mouth may decrease the effects of Fosamax. Do not take any other medicines within 30 minutes after a dose of Fosamax. Talk to your doctor before taking any other medicines during treatment with Fosamax.
Disclaimer
This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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Q: How does the online consultation for Fosamax work?
A: Online consultations utilizes the Internet to improve patient access to the physician. The patient no longer needs to receive a traditional physical exam by the physician. Now he simply completes an online questionnaire for Fosamax, and this questionnaire is then submitted to the physician using our secure order system. The online consultations can never take the place of traditional medicine, they do provide a valid means for patients to receive treatment for a number of conditions that, in many circumstances, do not actually require a physical exam.
Estrogen injections might help keep women's minds sharp as they age, a new study of female monkeys suggests.
For the study, published in this week's online issue of the Proceedings of the National Academy of Sciences, researchers at Mount Sinai School of Medicine, in New York City, removed the ovaries of four distinct groups of female rhesus monkeys. One group included old monkeys that received estrogen; a second group included old monkeys that did not receive estrogen; and there were two other groups of young monkeys that either received or did not receive estrogen.
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Removing the monkeys' ovaries induced menopause. The older monkeys had their ovaries removed around the time of perimenopause -- before the onset of full menopause.
Estrogen treatment involved pure estradiol injections every 21 days. The researchers periodically tested the monkeys on a series of cognitive tasks over the course of more than two years.
Older monkeys that were treated with estrogen performed almost as well as the younger monkeys on the mind-challenging tests, the researchers reported, while untreated older monkeys showed dramatic cognitive declines.
Surprisingly, the younger monkeys performed equally well whether or not they were treated with estrogen.
The study also found that the estrogen-treated monkeys showed brain changes associated with the prevention of cognitive decline. On the other hand, the older untreated monkeys showed no signs of these changes.
The findings suggest that the debate over whether hormone replacement therapy is beneficial may not be over, according to study co-author John H. Morrison, dean of basic sciences and the graduate school of biological sciences at Mount Sinai.
"There's been a great deal of confusion as to whether estrogen helps or harms postmenopausal women, and our findings tell us is that there is a very critical window of opportunity in which estrogen may be helpful," he said in a prepared statement.
He noted that this critical window could be around the time of perimenopause, when estrogen may be able to protect the brain from cognitive decline.
"Estrogen levels decline in old age, so the brain may need a certain amount of circulating estrogen to remain supple. Timing may be everything," Morrison said.
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